Date of event
Wednesday, April 27, 2022 - 12:00 pm -
Wednesday, April 27, 2022 - 1:00 pm
Continuing Education Credits
Add to Calendar 2022-04-27 12:00:00 2022-04-27 13:00:00 Webinar: The Art and Science of Managing Acute on Chronic Liver Failure AASLD America/New_York public

Content Contributor

Acute on Chronic Liver Failure SIG


  • Vinay Sundaram, MD, MS
  • Jennifer C. Lai, MD, MBA
  • Arpan Patel, MD, PhD


  • James Hanje, MD, FAASLD
  • Ruben Hernaez, MD, MPH, PhD


In this webinar, we will introduce a case-based presentation focused on management principles for the patient with Acute on Chronic Liver Failure. Specific scenarios includes whom to transplant, along with a discussion on the various international assessment systems (NACSELD, CLIF-ACLF, AARC ACLF). We will also discuss the impact of frailty, deconditioning and sarcopenia in hospitalized patients with ACLF. We will evaluate common challenging clinical scenarios such as unexplained leukocytosis, acute renal failure, and others. Finally, how to integrate a multidisciplinary team approach to the care of these patients with a focus on a Concurrent Care Model with Palliative Medicine.


Presenter Bios

Vinay Sundaram, MD, MS

Vinay Sundaram, MD, MS is currently a transplant hepatologist at Cedars-Sinai Medical Center, where he serves as the director of hepatology outcomes research and assistant medical director of liver transplantation. He went to medical school at New York University, followed by residency in internal medicine at the University of Virginia and gastroenterology fellowship at the University of Pittsburgh, where he also earned a Master of Science degree in clinical research. He then completed his training in transplant hepatology at Beth Israel Deaconess medical center. Dr. Sundaram has research interests in a variety of topics in hepatology, including acute on chronic liver failure, portal hypertension and post-transplant outcomes. He has first several publications regarding acute on chronic liver failure through analysis of public registries in high-impact journals including Gastroenterology, Hepatology and Journal of Hepatology. He is actively involved in AASLD and participates as chair of the Clinical Practice SIG education subcommittee, member of the ACLF SIG education committee and incoming chair of the membership and mentorship committee. He also serves on the editorial board for Hepatology and Hepatology Communications.

Photo of Dr. Sundaram


Jennifer C. Lai, MD, MBA

Jennifer C. Lai, MD, MBA is a general/transplant hepatologist, associate professor of medicine at the University of California, San Francisco (UCSF) and director of the UCSF Advancing Research in Clinical Hepatology (ARCH) program. Her mission is to improve the lives of patients with end-stage liver disease both at an individual level—through exceptional patient-centered care—and at a system-wide level—through rigorous clinical investigation and effective dissemination of impactful research.  Her research lies at the intersection of hepatology, liver transplantation, and geriatrics, focusing on the application of aging research principles to the care of liver transplant patients across their life-long journey from diagnosis of advanced chronic liver disease through long after liver transplantation.  The foundation for her research is the NIH-funded Multi-Center Functional Assessment in Liver Transplantation (FrAILT) Study.

Dr. Lai earned her undergraduate degree from Stanford University and combined MD/MBA degrees from Tufts University. She completed residency at the New York Presbyterian Hospital-Columbia followed by gastroenterology and transplant hepatology fellowships at UCSF. She serves as Associate Editor for the American Journal of Transplantation, member for the Editorial Boards for Hepatology and for Liver Transplantation and standing member on the FDA Gastrointestinal Drug Advisory Committee.

Photo of Dr. Lai


Arpan A. Patel, MD, PhD

Arpan A. Patel, MD, PhD is a transplant hepatologist and health services researcher at the David Geffen School of Medicine at UCLA. He is also a staff physician at the West Los Angeles Veterans Affairs Center and core investigator at the VA Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP) in Los Angeles. He performed his residency in Internal Medicine at the Hospital of the University of Pennsylvania, followed by fellowship in gastroenterology at UCLA and fellowship in Transplant Hepatology at Mount Sinai. He completed a PhD in Health Policy and Management at the Fielding School of Public Health at UCLA in 2020.

Dr. Patel’s career goal is to ensure that patients with advanced liver disease receive high-value care that optimizes their quality of life. His research goal is to understand ways that principles of palliative care can be integrated in management of these patients and their caregivers.

Photo of Dr. Patel


Moderator Bios

Adam James Hanje, MD

Adam James Hanje, MD, is the Co-Medical Director of the Ohio Health/Ohio Gastroenterology Group Comprehensive Liver Center in Columbus, Ohio. He is board certified in both Gastroenterology and Transplant Hepatology and an AASLD Fellow. He received his training in Gastroenterology and Transplant Hepatology from The Ohio State University and University of California, San Francisco. He served on faculty at The Ohio State Wexner Medical Center from 2008–2021, where he served as Director of Hepatology, helping build a large, clinically active, academic comprehensive Liver and Liver Transplant program. In 2014, he started an ACGME-accredited Transplant Hepatology fellowship program at Ohio State, serving as Program Director.

Dr. Hanje was promoted to full Professor of Clinical Medicine in 2020. In 2021, he left Ohio State to serve as the Co-Medical Director for the Ohio Health HealthCare System to build a Comprehensive Liver Center. Throughout his career, he has served as the Principal Investigator on numerous studies and was the site PI for the Acute Liver Failure Study Group (ALFSG), an NIH/NIDDK funded consortium that ran from 1997 through 2020, dedicated to the study of Acute Liver Failure. He has been a member of AASLD throughout his career and was selected as an AASLD Fellow in 2018.

Photo of Dr. Hanje


Ruben Hernaez, MD, MPH, PhD

Ruben Hernaez, MD, MPH, PhD is an American, Spanish-trained physician, triple board-certified in Internal Medicine, Gastroenterology, and Transplant Hepatology. Since he joined Baylor College of Medicine and Michael E DeBakey VA in August 2016 in Houston, he has been pursuing the triple threat: to boost hepatology education of residents and fellows, have clinical excellence and to excel in hepatology research. His interests are epidemiology, research outcomes, palliative care and Acute-on-chronic liver failure.

Photo of Dr. Hernaez